Quantitative imaging of the T cell antitumor response by positron-emission tomography.

  title={Quantitative imaging of the T cell antitumor response by positron-emission tomography.},
  author={Purnima Dubey and Helen C Su and Nona Adonai and Shouying Du and Antonio Rosato and Jonathan Braun and Sanjiv Sam Gambhir and Owen N Witte},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={100 3},
We describe a noninvasive, quantitative, and tomographic method to visualize lymphocytes within the whole animal. We used positron-emission tomography (PET) to follow the localization of adoptively transferred immune T lymphocytes. Splenic T cells from animals that had rejected a Moloney murine sarcoma virus/Moloney murine leukemia virus (M-MSV/M-MuLV)-induced tumor were marked with a PET reporter gene, injected into tumor-bearing mice, and imaged in a microPET by using a substrate specific for… CONTINUE READING
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Immune T lymphocytes preferentially home to the antigen-positive tumor Tumor % ID g Immune T cells Naive T cells M-MSV M-MuLV 2.0

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