Quantitative imaging of scattering changes associated with epithelial proliferation, necrosis, and fibrosis in tumors using microsampling reflectance spectroscopy.

@article{Krishnaswamy2009QuantitativeIO,
  title={Quantitative imaging of scattering changes associated with epithelial proliferation, necrosis, and fibrosis in tumors using microsampling reflectance spectroscopy.},
  author={Venkataramanan Krishnaswamy and P. Jack Hoopes and Kimberley S. Samkoe and Julia A O'Hara and Tayyaba Hasan and Brian W. Pogue},
  journal={Journal of biomedical optics},
  year={2009},
  volume={14 1},
  pages={014004}
}
Highly localized reflectance measurements can be used to directly quantify scatter changes in tissues. We present a microsampling approach that is used to raster scan tumors to extract parameters believed to be related to the tissue ultrastructure. A confocal reflectance imager was developed to examine scatter changes across pathologically distinct regions within tumor tissues. Tissue sections from two murine tumors, AsPC-1 pancreas tumor and the Mat-LyLu Dunning prostate tumor, were imaged… CONTINUE READING

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