Quantitative imaging of lymphatic function with liposomal indocyanine green.

  title={Quantitative imaging of lymphatic function with liposomal indocyanine green.},
  author={Steven T Proulx and Paola Luciani and Stefanie Derzsi and Matthias Rinderknecht and Viviane Mumprecht and Jean-Christophe Leroux and Michael Detmar},
  journal={Cancer research},
  volume={70 18},
Lymphatic vessels play a major role in cancer progression and in postsurgical lymphedema, and several new therapeutic approaches targeting lymphatics are currently being developed. Thus, there is a critical need for quantitative imaging methods to measure lymphatic flow. Indocyanine green (ICG) has been used for optical imaging of the lymphatic system, but it is unstable in solution and may rapidly enter venous capillaries after local injection. We developed a novel liposomal formulation of ICG… CONTINUE READING


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