Quantitative imaging of energy expenditure in human brain

@article{Zhu2012QuantitativeIO,
  title={Quantitative imaging of energy expenditure in human brain},
  author={Xiao-Hong Zhu and Hongyan Qiao and Fei Du and Qiang Xiong and Xiao Liu and Xiaoliang Zhang and Kamil Ugurbil and Wei James Chen},
  journal={NeuroImage},
  year={2012},
  volume={60},
  pages={2107-2117}
}
Despite the essential role of the brain energy generated from ATP hydrolysis in supporting cortical neuronal activity and brain function, it is challenging to noninvasively image and directly quantify the energy expenditure in the human brain. In this study, we applied an advanced in vivo(31)P MRS imaging approach to obtain regional cerebral metabolic rates of high-energy phosphate reactions catalyzed by ATPase (CMR(ATPase)) and creatine kinase (CMR(CK)), and to determine CMR(ATPase) and CMR(CK… CONTINUE READING

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