Quantitative imaging of alveolar recruitment with hyperpolarized gas MRI during mechanical ventilation.

@article{Cereda2011QuantitativeIO,
  title={Quantitative imaging of alveolar recruitment with hyperpolarized gas MRI during mechanical ventilation.},
  author={Maurizio F Cereda and Kiarash Emami and Stephen John Kadlecek and Yi Xin and Puttisarn Mongkolwisetwara and Harrilla Profka and Amy Barulic and Stephen Pickup and Sven M{\aa}nsson and Per Wollmer and Masaru Ishii and Clifford S. Deutschman and Rahim R. Rizi},
  journal={Journal of applied physiology},
  year={2011},
  volume={110 2},
  pages={
          499-511
        }
}
The aim of this study was to assess the utility of (3)He MRI to noninvasively probe the effects of positive end-expiratory pressure (PEEP) maneuvers on alveolar recruitment and atelectasis buildup in mechanically ventilated animals. Sprague-Dawley rats (n = 13) were anesthetized, intubated, and ventilated in the supine position ((4)He-to-O(2) ratio: 4:1; tidal volume: 10 ml/kg, 60 breaths/min, and inspiration-to-expiration ratio: 1:2). Recruitment maneuvers consisted of either a stepwise… CONTINUE READING

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