Quantitative identification of differentially methylated loci based on relative entropy for matched case-control data.

Abstract

AIM As an important epigenetic modification, DNA methylation plays a critical role in regulating multiple biological processes and diseases. Many efforts have been devoted to identifying differentially methylated loci (DML) between cases and controls. MATERIALS & METHODS However, most present methods are statistical and are limited in handling methylation… (More)
DOI: 10.2217/epi.13.58

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