Quantitative hypermethylation of NMDAR2B in human gastric cancer.

  title={Quantitative hypermethylation of NMDAR2B in human gastric cancer.},
  author={Jun-wei Liu and Myoung Sook Kim and Jatin Kumar Nagpal and Keishi Yamashita and Luana Poeta and Xiaofei Chang and Juna Lee and Hannah Lui Park and Carmen Jer{\'o}nimo and William H Westra and Masaki Mori and Chulso Moon and Barry Trink and David Sidransky},
  journal={International journal of cancer},
  volume={121 9},
NMDA receptor Type 2B (NMDAR2B) is a candidate TSG first identified in esophageal squamous cell carcinoma (ESCC). To evaluate NMDAR2B methylation in gastric cancer progression, we performed quantitative methylation-specific PCR (MSP), RT-PCR and immnunohistochemistry (IHC) in primary gastric tissues and colony formation assays in gastric cancer cell lines. We found that the expression of NMDAR2B was reactivated by the demethylating agent, 5-aza-2'-deoxycytidine, with or without trichostatin A… CONTINUE READING


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