Quantitative genetics of vector competence for dengue-2 virus in Aedes aegypti.

  title={Quantitative genetics of vector competence for dengue-2 virus in Aedes aegypti.},
  author={Christopher F. Bosio and Barry J Beaty and William C. Black},
  journal={The American journal of tropical medicine and hygiene},
  volume={59 6},
A quantitative genetic study of the ability of Aedes aegypti to propagate dengue-2 (DEN-2) virus in the midgut and in a disseminated infection in the head was conducted with a standard half-sib breeding design. Aedes aegypti aegypti and A. aegypti formosus differ markedly in oral susceptibility to DEN-2 virus. Mosquitoes were orally infected and, after an extrinsic incubation period of 14 days, virus titer (by tissue culture infectious dose, 50% endpoint) was determined in the midgut (MT) and… CONTINUE READING
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