Quantitative gene expression assessment identifies appropriate cell line models for individual cervical cancer pathways

@article{Carlson2006QuantitativeGE,
  title={Quantitative gene expression assessment identifies appropriate cell line models for individual cervical cancer pathways},
  author={Mark W Carlson and Vishwanath R. Iyer and Edward M. Marcotte},
  journal={BMC Genomics},
  year={2006},
  volume={8},
  pages={117 - 117}
}
Cell lines have been used to study cancer for decades, but truly quantitative assessment of their performance as models is often lacking. We used gene expression profiling to quantitatively assess the gene expression of nine cell line models of cervical cancer. We find a wide variation in the extent to which different cell culture models mimic late-stage invasive cervical cancer biopsies. The lowest agreement was from monolayer HeLa cells, a common cervical cancer model; the highest agreement… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 15 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 43 references

Similar Papers

Loading similar papers…