Quantitative gas chromatographic analysis of [1-(4-piperidinyl)-1,3-dihydro-2H-benzimidazole-2-one], the basic metabolite of bezitramide (Burgodin), in human urine.
@article{Baere1998QuantitativeGC, title={Quantitative gas chromatographic analysis of [1-(4-piperidinyl)-1,3-dihydro-2H-benzimidazole-2-one], the basic metabolite of bezitramide (Burgodin), in human urine.}, author={S. D. De Baere and W. Lambert and A. D. De leenheer}, journal={Journal of analytical toxicology}, year={1998}, volume={22 1}, pages={ 18-26 } }
A gas chromatographic procedure with nitrogen-phosphorus detection was developed for the quantitative determination of 1-(4-piperidinyl)-1,3-dihydro-2H-benzimidazole-2-one, the basic metabolite of the narcotic analgesic bezitramide (Burgodin), in urine. Gas chromatography with mass spectrometric detection was used for confirmation. An internal standard with great structural resemblance to the basic metabolite was synthesized in our laboratory. For the isolation of the compound from urine, a… CONTINUE READING
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Quantitative gas chromatographic analysis of 3-cyano-3,3-diphenylpropionic acid, the acidic metabolite of bezitramide (Burgodin), in urine.
- Medicine, Chemistry
- Journal of analytical toxicology
- 1996
- 5
- PDF
Determination of the metabolites of bezitramide in urine. II. The basic metabolite.
- Chemistry, Medicine
- Journal of chromatography
- 1978
- 5
THE VALIDATION CRITERIA FOR ANALYTICAL METHODS USED IN PHARMACY PRACTICE RESEARCH
- Medicine
- Journal of clinical pharmacy and therapeutics
- 1989
- 34