Quantitative gas chromatographic analysis of [1-(4-piperidinyl)-1,3-dihydro-2H-benzimidazole-2-one], the basic metabolite of bezitramide (Burgodin), in human urine.

@article{DeBaere1998QuantitativeGC,
  title={Quantitative gas chromatographic analysis of [1-(4-piperidinyl)-1,3-dihydro-2H-benzimidazole-2-one], the basic metabolite of bezitramide (Burgodin), in human urine.},
  author={Siegrid De Baere and Willy E E Lambert and A P De leenheer},
  journal={Journal of analytical toxicology},
  year={1998},
  volume={22 1},
  pages={
          18-26
        }
}
A gas chromatographic procedure with nitrogen-phosphorus detection was developed for the quantitative determination of 1-(4-piperidinyl)-1,3-dihydro-2H-benzimidazole-2-one, the basic metabolite of the narcotic analgesic bezitramide (Burgodin), in urine. Gas chromatography with mass spectrometric detection was used for confirmation. An internal standard with great structural resemblance to the basic metabolite was synthesized in our laboratory. For the isolation of the compound from urine, a… 
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Chapter 23 Sampling and sample preparation for clinical and pharmaceutical analysis
Publisher Summary Drug analysis in biological samples and pharmaceutical products is very important for therapeutic drug monitoring (TDM), pharmacokinetic studies, and screening of illicit drugs and

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TLDR
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