Quantitative gas chromatographic analysis of [1-(4-piperidinyl)-1,3-dihydro-2H-benzimidazole-2-one], the basic metabolite of bezitramide (Burgodin), in human urine.

S. D. De Baere; W. Lambert; A. D. De leenheer

DOI:10.1093/JAT/22.1.18

Corpus ID: 23199260

Quantitative gas chromatographic analysis of [1-(4-piperidinyl)-1,3-dihydro-2H-benzimidazole-2-one], the basic metabolite of bezitramide (Burgodin), in human urine.

@article{Baere1998QuantitativeGC,
  title={Quantitative gas chromatographic analysis of [1-(4-piperidinyl)-1,3-dihydro-2H-benzimidazole-2-one], the basic metabolite of bezitramide (Burgodin), in human urine.},
  author={S. D. De Baere and W. Lambert and A. D. De leenheer},
  journal={Journal of analytical toxicology},
  year={1998},
  volume={22 1},
  pages={
          18-26
        }
}

S. D. De Baere, W. Lambert, A. D. De leenheer

Published 1998

Medicine, Chemistry

Journal of analytical toxicology

A gas chromatographic procedure with nitrogen-phosphorus detection was developed for the quantitative determination of 1-(4-piperidinyl)-1,3-dihydro-2H-benzimidazole-2-one, the basic metabolite of the narcotic analgesic bezitramide (Burgodin), in urine. Gas chromatography with mass spectrometric detection was used for confirmation. An internal standard with great structural resemblance to the basic metabolite was synthesized in our laboratory. For the isolation of the compound from urine, a… CONTINUE READING

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