Quantitative flow cytometry shows activation of the TNF-alpha system but not of the IL-2 system at the single cell level in renal replacement therapy.

@article{Overbeeke2001QuantitativeFC,
  title={Quantitative flow cytometry shows activation of the TNF-alpha system but not of the IL-2 system at the single cell level in renal replacement therapy.},
  author={Iza C van Riemsdijk-van Overbeeke and Carla C. Baan and Christiaan J Knoop and E H M Loonen and Robert Zietse and Willem W Weimar},
  journal={Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association},
  year={2001},
  volume={16 7},
  pages={1430-5}
}
BACKGROUND Immunological dysfunction in patients on haemodialysis may be related to imbalanced cytokine systems, such as tumour necrosis factor (TNF)-alpha and interleukin (IL)-2. Despite activation of these systems, haemodialysis patients show high susceptibility for infections and malignancies, and have a poor immunological reaction to T-cell-dependent antigens, like hepatitis B vaccination. In this study we have determined the activation status of the two different cytokine systems, at the… CONTINUE READING