Quantitative expansion of structural genomic alterations in the spectrum of neuroendocrine lung carcinomas.

@article{Gugger2002QuantitativeEO,
  title={Quantitative expansion of structural genomic alterations in the spectrum of neuroendocrine lung carcinomas.},
  author={Mathias Gugger and Elisabeth Burckhardt and Andreas Kappeler and Hans Hirsiger and Jean Albert Laissue and Luca Mazzucchelli},
  journal={The Journal of pathology},
  year={2002},
  volume={196 4},
  pages={408-15}
}
The pathogenesis and interrelationships of neuroendocrine lung carcinomas are not well understood. Tissue macro-arrays prepared from surgical resection specimens from 35 patients with typical carcinoid (TC), six with atypical carcinoid (AC), 13 with large cell neuroendocrine carcinoma (LCNEC), and 15 with small cell lung carcinoma (SCLC) were investigated by fluorescence in situ hybridization (FISH) and immunohistochemistry. Hybridizations with locus-specific DNA probes demonstrated a high… CONTINUE READING
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