Quantitative evidence against inactivation of self-reactive B-cell clones.

Abstract

The frequencies of murine B-cell precursors developing into clones secreting antibodies which bind to autologous (mouse) or heterologous (rabbit or human) forms of the same protein antigen (myosin and albumin) were determined in an attempt to directly test the hypothesis of higher decay rates of B lymphocytes exposed to self-antigens. The results exclude, on a quantitative basis, any form of inactivation or deletion of such cells.

Cite this paper

@article{Karray1986QuantitativeEA, title={Quantitative evidence against inactivation of self-reactive B-cell clones.}, author={Saoussen Karray and Peggy Lymberi and Stratis Avrameas and Ant{\'o}nio Coutinho}, journal={Scandinavian journal of immunology}, year={1986}, volume={23 4}, pages={475-80} }