Quantitative evaluation of the relationship between COMP promoter methylation and the susceptibility and curve progression of adolescent idiopathic scoliosis

Abstract

The cartilage oligomeric matrix protein (COMP) was reported to be down-regulated in adolescent idiopathic scoliosis (AIS). The purposes of the study were to evaluate the roles of COMP promoter methylation on the abnormal gene expression and the epigenetic phenotype in AIS. DNA samples of 50 AIS patients and 50 healthy controls were analyzed. Five CpG sites… (More)
DOI: 10.1007/s00586-017-5309-y

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