Quantitative evaluation of partial deletions of the DAZ gene cluster.

  title={Quantitative evaluation of partial deletions of the DAZ gene cluster.},
  author={G. D'Amico and D. Di Benedetto and F. M. Pezzino and V. Giuffrida and M. Libra and M. Fichera and Grazia Mauceri and G. Rappazzo and R. D'agata and E. Vicari and S. Travali and A. Calogero},
  journal={International journal of molecular medicine},
  volume={17 5},
  • G. D'Amico, D. Di Benedetto, +9 authors A. Calogero
  • Published 2006
  • Biology, Medicine
  • International journal of molecular medicine
  • Partial deletions of the DAZ gene cluster are thought to cause spermatogenesis impairment. The presence of homologous copies of this gene in the Y chromosome does not allow PCR to be used for the identification of this abnormality. Hence, sequence family variants (SFV), following amplification of sY581, sY587 and sY586 and subsequent enzymatic digestion with Sau3A, DraI and TaqI, respectively, and the dual fiber fluorescence in situ hybridization (FISH) have been used to this aim. However, SFV… CONTINUE READING
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