Quantitative evaluation of partial deletions of the DAZ gene cluster.

@article{DAmico2006QuantitativeEO,
  title={Quantitative evaluation of partial deletions of the DAZ gene cluster.},
  author={Giovanbattista D'Amico and Daniela Di Benedetto and Franca Maria Pezzino and Vincenza Giuffrida and Massimo Libra and Marco Fichera and Grazia Mauceri and Giancarlo Rappazzo and Rosario D'Agata and Enzo Vicari and Salvatore Travali and Aldo Eugenio Calogero},
  journal={International journal of molecular medicine},
  year={2006},
  volume={17 5},
  pages={
          785-9
        }
}
Partial deletions of the DAZ gene cluster are thought to cause spermatogenesis impairment. The presence of homologous copies of this gene in the Y chromosome does not allow PCR to be used for the identification of this abnormality. Hence, sequence family variants (SFV), following amplification of sY581, sY587 and sY586 and subsequent enzymatic digestion with Sau3A, DraI and TaqI, respectively, and the dual fiber fluorescence in situ hybridization (FISH) have been used to this aim. However, SFV… CONTINUE READING

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