Quantitative evaluation of neuronal loss in the dorsal hippocampus in rats with long-term pilocarpine seizures

@article{Zhao1994QuantitativeEO,
  title={Quantitative evaluation of neuronal loss in the dorsal hippocampus in rats with long-term pilocarpine seizures},
  author={Liu Zhao and Takeki Nagao and G. Clarissa Desjardins and Pierre Gloor and Massimo Avoli},
  journal={Epilepsy Research},
  year={1994},
  volume={17},
  pages={237-247}
}
Systemic administration of the cholinergic agonist pilocarpine (350-400 mg/kg, i.p.) to rats induces acute behavioral and EEG status epilepticus followed by apparent complete neurological recovery. In rats receiving higher doses of pilocarpine (i.e., 380-400 mg/kg), recurrent seizures reappear 2-2.5 weeks later and continue to occur as long as the rats are kept alive. Stereological estimates of neurons in regions CA1, CA3 and the dentate granule cell layer in the dorsal hippocampus show a dose… Expand
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