Quantitative evaluation of liver-specific promoters from retroviral vectors after in vivo transduction of hepatocytes.

@article{Hafenrichter1994QuantitativeEO,
  title={Quantitative evaluation of liver-specific promoters from retroviral vectors after in vivo transduction of hepatocytes.},
  author={D G Hafenrichter and Xianglin Wu and Steven D. Rettinger and S C Kennedy and Melvin Wayne Flye and Katherine Parker Ponder},
  journal={Blood},
  year={1994},
  volume={84 10},
  pages={3394-404}
}
Hepatic gene therapy could be used to treat a number of inherited blood diseases such as hemophilia or thrombophilia. Although liver-directed retroviral transduction can result in long-term gene expression in vivo, the low level of protein production has limited its clinical application. We reasoned that the insertion of liver-specific promoters into retroviral vectors would increase gene expression in vivo. The 347-bp human alpha 1-antitrypsin (hAAT), the 810-bp murine albumin (mAIb), the 490… CONTINUE READING

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