Quantitative evaluation of blood-brain barrier permeability following middle cerebral artery occlusion in rats

@article{Belayev1996QuantitativeEO,
  title={Quantitative evaluation of blood-brain barrier permeability following middle cerebral artery occlusion in rats},
  author={Ludmila Belayev and Raul Busto and Weizhao Zhao and Myron D. Ginsberg},
  journal={Brain Research},
  year={1996},
  volume={739},
  pages={88-96}
}

QUANTITATIVE EVALUATION OF BLOOD BRAIN BARRIER PERMEABILITY IN TRANSIENT FOCAL CEREBRAL ISCHEMIA IN RATS

It is indicated that quantitative detection of Evans blue extravasation technique is capable of measuring the alterations of BBB permeability in cerebral ischemia in the rat, indicating severe motor disabilities due to cerebral ischemic injury.

Late changes in blood–brain barrier permeability in a rat tMCAO model of stroke detected by gadolinium-enhanced MRI

The results indicate a significant late opening of the blood–brain barrier, which may indicate an optimal time for drug delivery across the BBB, when it is especially suited to drugs targeting delayed processes.

Transient Middle Cerebral Artery Occlusion by Intraluminal Suture: I. Three-Dimensional Autoradiographic Image-Analysis of Local Cerebral Glucose Metabolism—Blood Flow Interrelationships during Ischemia and Early Recirculation

Regression analysis indicated that depressed glucose utilization in a highly reproducible model of transient middle cerebral artery occlusion for 2 hours induced graded LCBF decrements affecting ipsilateral cortical and basal ganglionic regions, and was determined largely by the intensity of antecedent ischemia.

Severe Blood–Brain Barrier Disruption and Surrounding Tissue Injury

Severe vascular disruption, as labeled with high-molecular-weight dextran-fluorescein isothiocyanate leakage, is associated with severe tissue injury and may be useful in further studies of the pathoanatomic mechanisms of vascular disruption-mediated tissue injury.
...

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