Quantitative evaluation of RASSF1A methylation in the non-lesional, regenerative and neoplastic liver

@article{Gioia2005QuantitativeEO,
  title={Quantitative evaluation of RASSF1A methylation in the non-lesional, regenerative and neoplastic liver},
  author={Sonia Di Gioia and Paolo Bianchi and Annarita Destro and Fabio Grizzi and Alberto Malesci and Luigi Laghi and Massimo Levrero and A. Morabito and Massimo G Roncalli},
  journal={BMC Cancer},
  year={2005},
  volume={6},
  pages={89 - 89}
}
Epigenetic changes during ageing and their relationship with cancer are under the focus of intense research. RASSF1A and NORE1A are novel genes acting in concert in the proapoptotic pathway of the RAS signalling. While NORE1A has not been previously investigated in the human liver, recent reports have suggested that RASSF1A is frequently epigenetically methylated not only in HCC but also in the cirrhotic liver. To address whether epigenetic changes take place in connection to age and/or to the… CONTINUE READING