Quantitative evaluation of BBB permeability after embolic stroke in rat using MRI.

@article{Jiang2005QuantitativeEO,
  title={Quantitative evaluation of BBB permeability after embolic stroke in rat using MRI.},
  author={Quan Jiang and James R. Ewing and Guang Liang Ding and Li Zhang and Zheng Gang Zhang and Lian Li and Polly A Whitton and Mei Lu and Jiani 4 Hu and Qing Jiang Li and Robert A. Knight and Michael Chopp},
  journal={Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism},
  year={2005},
  volume={25 5},
  pages={
          583-92
        }
}
We sought to identify magnetic resonance imaging (MRI) parameters that can identify as well as predict disruption of the blood-brain barrier (BBB) after embolic stroke in the rat. Rats subjected to embolic stroke with (n=13) and without (n=13) rt-PA treatment were followed with MRI using quantitative permeability-related parameters, consisting of: transfer constant (K(i)) of Gd- DTPA, the distribution volume (V(p)) of the mobile protons, and the inverse of the apparent forward transfer rate for… CONTINUE READING
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