Quantitative estimates of sequence divergence for comparative analyses of mammalian genomes.

Abstract

Comparative sequence analyses on a collection of carefully chosen mammalian genomes could facilitate identification of functional elements within the human genome and allow quantification of evolutionary constraint at the single nucleotide level. High-resolution quantification would be informative for determining the distribution of important positions… (More)

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@article{Cooper2003QuantitativeEO, title={Quantitative estimates of sequence divergence for comparative analyses of mammalian genomes.}, author={Gregory M. Cooper and Michael Brudno and Eric D. Green and Serafim Batzoglou and Arend Sidow}, journal={Genome research}, year={2003}, volume={13 5}, pages={813-20} }