Quantitative effects of Nf1 inactivation on in vivo hematopoiesis.

  title={Quantitative effects of Nf1 inactivation on in vivo hematopoiesis.},
  author={Yuchun Zhang and Brigit R Taylor and Kevin Shannon and David W Clapp},
  journal={The Journal of clinical investigation},
  volume={108 5},
The NF1 tumor-suppressor gene is frequently inactivated in juvenile myelomonocytic leukemia, and Nf1 mutant mice model this myeloproliferative disorder (MPD). Competitive repopulation assays were performed to quantify the proliferative advantage of Nf1(-/-) hematopoietic cells in vivo. Nf1 mutant stem cells demonstrated a growth advantage that was greatest in myeloid lineage cells and least pronounced in T lymphocytes. Surprisingly, although low numbers of Nf1-deficient cells consistently… CONTINUE READING

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