Quantitative effect of CYP2D6 genotype and inhibitors on tamoxifen metabolism: implication for optimization of breast cancer treatment.

@article{Borges2006QuantitativeEO,
  title={Quantitative effect of CYP2D6 genotype and inhibitors on tamoxifen metabolism: implication for optimization of breast cancer treatment.},
  author={Silvana Borges and Zeruesenay Desta and Lang Li and Todd C. Skaar and Bryan A. Ward and Anne Thi Phuong Nguyen and Yan Jin and Anna Maria Storniolo and D. Michele Nikoloff and Lin Wu and Grant Hillman and Daniel F. Hayes and Vered Stearns and David A. Flockhart},
  journal={Clinical pharmacology and therapeutics},
  year={2006},
  volume={80 1},
  pages={
          61-74
        }
}
BACKGROUND AND OBJECTIVES N-Desmethyltamoxifen (NDM), a major primary metabolite of tamoxifen, is hydroxylated by cytochrome P450 (CYP) 2D6 to yield endoxifen. Because of its high antiestrogenic potency, endoxifen may play an important role in the clinical activity of tamoxifen. We conducted a prospective trial in 158 patients with breast cancer who were taking tamoxifen to further understand the effect of CYP2D6 genotype and concomitant medications on endoxifen plasma concentrations. METHODS… CONTINUE READING
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