Quantitative drug benefit-risk assessment: utility of modeling and simulation to optimize drug safety in older adults.


BACKGROUND More than 50 % of individuals affected by adverse drug events (ADEs) are older adults. Establishing a drug dosing regimen that balances benefit and risk, and minimizes ADEs in older populations can be challenging. OBJECTIVE The aim of this study is to evaluate the use of modeling, simulation, and risk-benefit acceptability methods to establish… (More)
DOI: 10.1177/1060028013514376


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