Quantitative discrimination of hepatic reticuloendothelial clearance and phagocytic killing.

@article{Klein1994QuantitativeDO,
  title={Quantitative discrimination of hepatic reticuloendothelial clearance and phagocytic killing.},
  author={Andrew S. Klein and M Zhadkewich and Joseph B. Margolick and Jerry A. Winkelstein and Gregory B. Bulkley},
  journal={Journal of leukocyte biology},
  year={1994},
  volume={55 2},
  pages={248-52}
}
An in vivo assay to quantify simultaneously two important components of hepatic reticuloendothelial system (RES) function--clearance and phagocytic killing--was developed in the rat. Intravenously injected E. coli labeled with Na51Cr and 5-[125I]-iodo-2'-deoxyuridine were cleared rapidly from the blood primarily by the liver. While hepatic 51Cr levels remained stable for 24 h following inoculation and provided a reliable measurement of clearance, hepatic 125I decreased over time. Hepatic 125I… CONTINUE READING