Quantitative disassembly and reassembly of human papillomavirus type 11 viruslike particles in vitro.

@article{McCarthy1998QuantitativeDA,
  title={Quantitative disassembly and reassembly of human papillomavirus type 11 viruslike particles in vitro.},
  author={Michael K. McCarthy and Wendy I. White and Frances J. Palmer-Hill and S Koenig and JoAnn A Suzich},
  journal={Journal of virology},
  year={1998},
  volume={72 1},
  pages={32-41}
}
The human papillomavirus (HPV) capsid is primarily composed of a structural protein denoted L1, which forms both pentameric capsomeres and capsids composed of 72 capsomeres. The L1 protein alone is capable of self-assembly in vivo into capsidlike structures referred to as viruslike particles (VLPs). We have determined conditions for the quantitative disassembly of purified HPV-11 L1 VLPs to the level of capsomeres, demonstrating that disulfide bonds alone are essential to maintaining long-term… CONTINUE READING
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