Quantitative differences in chemokine receptor engagement generate diversity in integrin-dependent lymphocyte adhesion.

@article{DAmbrosio2002QuantitativeDI,
  title={Quantitative differences in chemokine receptor engagement generate diversity in integrin-dependent lymphocyte adhesion.},
  author={Daniele D'Ambrosio and Cristina Albanesi and Rosmarie Lang and Giampiero Girolomoni and Francesco Sinigaglia and Carlo Laudanna},
  journal={Journal of immunology},
  year={2002},
  volume={169 5},
  pages={2303-12}
}
Chemokines control the specificity of lymphocyte homing. Numerous chemokines have been identified but the significance of redundancy in chemokine networks is unexplained. Here we investigated the biological significance of distinct chemokines binding to the same receptor. Among CCR4 ligands, skin vessels endothelial cells present C-C chemokine ligand (CCL) 17 but not CCL22 consistent with CCL17 involvement in T lymphocyte arrest on endothelial cells. However, CCL22 is much more powerful than… CONTINUE READING
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