Quantitative determination of dithiocarbamates in human plasma, serum, erythrocytes and urine: pharmacokinetics of broccoli sprout isothiocyanates in humans.

@article{Ye2002QuantitativeDO,
  title={Quantitative determination of dithiocarbamates in human plasma, serum, erythrocytes and urine: pharmacokinetics of broccoli sprout isothiocyanates in humans.},
  author={Lingxiang Ye and Albena T Dinkova-Kostova and Kristina L. Wade and Yuesheng Zhang and Theresa A. Shapiro and Paul Talalay},
  journal={Clinica chimica acta; international journal of clinical chemistry},
  year={2002},
  volume={316 1-2},
  pages={43-53}
}
BACKGROUND Humans are exposed to substantial quantities of isothiocyanates and glucosinolates from vegetables. Since dietary isothiocyanates are widely regarded as potentially important chemoprotectors against cancer, reliable methods for measuring the plasma and tissue pharmacokinetics of isothiocyanates and their dithiocarbamate metabolites are essential for defining dosing regimens. METHODS Isothiocyanates (ITC) and dithiocarbamates (DTC) react quantitatively with 1,2-benzenedithiol to… CONTINUE READING
113 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 113 extracted citations

Similar Papers

Loading similar papers…