Quantitative determination of dextromethorphan and three metabolites in urine by reverse-phase high-performance liquid chromatography.

@article{Park1984QuantitativeDO,
  title={Quantitative determination of dextromethorphan and three metabolites in urine by reverse-phase high-performance liquid chromatography.},
  author={Young Han Park and M P Kullberg and O N Hinsvark},
  journal={Journal of pharmaceutical sciences},
  year={1984},
  volume={73 1},
  pages={24-9}
}
A high-performance liquid chromatographic (HPLC) method for the quantitation of dextromethorphan (I) and its three metabolites, dextrorphan (II), 3-hydroxy-9 alpha,13 alpha,14 alpha-morphinan (III), and 3-methoxy-9 alpha,13 alpha,14 alpha-morphinan (IV), in urine was developed. For the analysis of nonconjugated compounds, urine samples at pH 11-11.5… CONTINUE READING