Quantitative determination of cocaine and its metabolites benzoylecgonine and ecgonine by gas-liquid chromatography.

@article{Javaid1975QuantitativeDO,
  title={Quantitative determination of cocaine and its metabolites benzoylecgonine and ecgonine by gas-liquid chromatography.},
  author={Javaid I. Javaid and Haroutune Dekirmenjian and Eric G. Brunngraber and John M Davis},
  journal={Journal of chromatography},
  year={1975},
  volume={110 1},
  pages={140-9}
}
A sensitive and reliable method was developed to determine quantitatively cocaine and its metabolites benzoylecgonine and ecgonine. The method involved the formation of fluoro derivatives which were separated on 3% and 5% OV-1 columns and detected in picomole quantities using an electron capture detector. Ecgonine and benzoylecgonine were derivatized with a… CONTINUE READING