Quantitative determination of atractylenolide III in rat plasma by liquid chromatography electrospray ionization mass spectrometry.

@article{Wang2006QuantitativeDO,
  title={Quantitative determination of atractylenolide III in rat plasma by liquid chromatography electrospray ionization mass spectrometry.},
  author={Rui Wang and Guangji Wang and Haiping Hao and Haitang Xie and Jinfeng Zhang and Feng Wu},
  journal={Journal of chromatography. B, Analytical technologies in the biomedical and life sciences},
  year={2006},
  volume={831 1-2},
  pages={
          36-41
        }
}
Atractylenolide III is a major active component in Atractylodes macrocephala. This paper describes a simple, rapid, specific and sensitive method for the quantification of atractylenolide III in rat plasma using a liquid-liquid extraction procedure followed by liquid chromatography mass spectrometric (LC-MS) analysis. A Kromasil 3.5 microm C(18) column (150 mm x 2.00 mm) was used as the analytical column. Linear detection responses were obtained for atractylenolide III concentration ranging… CONTINUE READING
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