Quantitative determination of anti-K (KEL1) IgG and IgG subclasses in the serum of severely alloimmunized pregnant women by ELISA.

@article{Ahaded2000QuantitativeDO,
  title={Quantitative determination of anti-K (KEL1) IgG and IgG subclasses in the serum of severely alloimmunized pregnant women by ELISA.},
  author={A Ahaded and Yves Brossard and Martine Debbia and Patrick Lambin},
  journal={Transfusion},
  year={2000},
  volume={40 10},
  pages={1239-45}
}
BACKGROUND Severe cases of HDN occur after the immunization of the mother with K (KEL1) antigen. To date, the only means of evaluating the concentration of anti-K in maternal serum is by titration with an indirect antiglobulin test (IAT). A more accurate estimation of the serum anti-K concentration is needed. STUDY DESIGN AND METHODS An ELISA technique was developed for the determination of the absolute concentration of anti-K IgG and IgG subclasses in the sera of alloimmunized patients. In… CONTINUE READING

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