Quantitative detection of small molecule/DNA complexes employing a force-based and label-free DNA-microarray.

@article{Ho2009QuantitativeDO,
  title={Quantitative detection of small molecule/DNA complexes employing a force-based and label-free DNA-microarray.},
  author={Dominik Ho and Christian Dose and Christian H Albrecht and Philip Severin and Katja Falter and Peter B. Dervan and Hermann Eduard Gaub},
  journal={Biophysical journal},
  year={2009},
  volume={96 11},
  pages={4661-71}
}
Force-based ligand detection is a promising method to characterize molecular complexes label-free at physiological conditions. Because conventional implementations of this technique, e.g., based on atomic force microscopy or optical traps, are low-throughput and require extremely sensitive and sophisticated equipment, this approach has to date found only limited application. We present a low-cost, chip-based assay, which combines high-throughput force-based detection of dsDNA.ligand… CONTINUE READING