Quantitative detection of nitroxyl upon trapping with glutathione and labeling with a specific fluorogenic reagent.

Abstract

Donors of nitroxyl (HNO) have shown promise for treatment of stroke, heart failure, alcoholism and cancer. However, comparing the pharmacological capacities of various donors is difficult without first quantifying the amount of HNO released from each donor. Detection and quantitation of HNO has been complicated by the rapid self-consumption of HNO through… (More)
DOI: 10.1016/j.freeradbiomed.2013.05.011

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