Quantitative detection of methylated ESR1 and 14-3-3-sigma gene promoters in serum as candidate biomarkers for diagnosis of breast cancer and evaluation of treatment efficacy.

@article{MartinezGalan2008QuantitativeDO,
  title={Quantitative detection of methylated ESR1 and 14-3-3-sigma gene promoters in serum as candidate biomarkers for diagnosis of breast cancer and evaluation of treatment efficacy.},
  author={Joaquina J Martinez-Galan and Blanca Torres and Rosario del Moral and Jos{\'e} Antonio Mu{\~n}oz-G{\'a}mez and David Mart{\'i}n-Oliva and Mercedes Villalobos and Mar{\'i}a Isabel N{\'u}{\~n}ez and Juan de Dios Luna and Francisco Javier Oliver and Jos{\'e} Mariano Ruiz de Almod{\'o}var},
  journal={Cancer biology & therapy},
  year={2008},
  volume={7 6},
  pages={
          958-65
        }
}
The aim of the present study was to investigate the association between gene hypermethylation and main clinicopathological features of breast cancer, including diagnosis and treatment response. A sensitive SYBR green methylation-specific PCR technique was used to analyze the utility of circulating DNA with CpG island hypermethylation of ESR1, APC, RARB, 14-3-3-sigma and E-cad gene promoter regions as breast cancer biomarkers. Analyses were conducted of preoperative sera from 106 women with… CONTINUE READING

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