Quantitative cytokine gene expression in CF airway.

  title={Quantitative cytokine gene expression in CF airway.},
  author={Marianne S Muhlebach and William t. Reed and Terry L Noah},
  journal={Pediatric pulmonology},
  volume={37 5},
Bronchoalveolar lavage fluid (BALF) in cystic fibrosis (CF) shows increased inflammation, which could be due to abnormal cytokine regulation. Bronchial epithelial cells and migratory inflammatory cells produce these cytokines, but few quantitative in vivo data are available comparing young CF patients with controls. We hypothesized that IL-8 mRNA abundance was higher in young CF vs. non-CF disease control patients in lung epithelium and inflammatory cells. Bronchial epithelial cells (BEC) were… CONTINUE READING