Quantitative control of MHC class II expression by the transactivator CIITA.

@article{Otten1998QuantitativeCO,
  title={Quantitative control of MHC class II expression by the transactivator CIITA.},
  author={Luc A. Otten and Viktor Steimle and S{\'e}verine Bontron and Bernard Mach},
  journal={European journal of immunology},
  year={1998},
  volume={28 2},
  pages={473-8}
}
Activation of T lymphocytes is quantitatively controlled by the level of expression of MHC class II molecules. Both constitutive and inducible expression of MHC class II genes is regulated by the transactivator CIITA, which is itself tightly regulated. Since the level of MHC class II molecules expressed is a functionally essential parameter, it was of interest to explore whether MHC class II expression is quantitatively controlled by the level of the transactivator. This report shows that in a… CONTINUE READING

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