Quantitative comparison of physical dependence on tertiary butanol and ethanol in mice: correlation with lipid solubility.

@article{McComb1979QuantitativeCO,
  title={Quantitative comparison of physical dependence on tertiary butanol and ethanol in mice: correlation with lipid solubility.},
  author={Joan McComb and Dora B. Goldstein},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1979},
  volume={208 1},
  pages={
          113-7
        }
}
Mice were made physically dependent on t-butanol and the withdrawal reaction was compared quantitatively with that produced by ethanol. The mice inhaled t-butanol vapor (50-140 mumol/1 of air) continuously for 1, 3, 6 or 9 days. Daily t-butanol blood levels were determined by gas chromatography, using ethanol as internal standard. After t-butanol exposure the mice were removed from the vapor chamber and the withdrawal reaction was quantitated by hourly scoring of convulsions elicited by… CONTINUE READING