Quantitative characterization of the transcriptional regulatory network in the yeast cell cycle

@article{Chen2004QuantitativeCO,
  title={Quantitative characterization of the transcriptional regulatory network in the yeast cell cycle},
  author={Hong-Chu Chen and Hsiao-Ching Lee and Tsai-Yun Lin and Wen-Hsiung Li and Bor-Sen Chen},
  journal={Bioinformatics},
  year={2004},
  volume={20 12},
  pages={1914-27}
}
MOTIVATION Genome-wide gene expression programs have been monitored and analyzed in the yeast Saccharomyces cerevisiae, but how cells regulate global gene expression programs in response to environmental changes is still far from being understood. We present a systematic approach to quantitatively characterize the transcriptional regulatory network of the yeast cell cycle. For the interpretative purpose, 20 target genes were selected because their expression patterns fluctuated in a periodic… CONTINUE READING
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