Quantitative characterization of T-cell repertoire in allogeneic hematopoietic stem cell transplant recipients

@inproceedings{Yew2015QuantitativeCO,
  title={Quantitative characterization of T-cell repertoire in allogeneic hematopoietic stem cell transplant recipients},
  author={P Y Yew and Houda Alachkar and Rui Yamaguchi and Kazuma Kiyotani and Huiwen Fang and Kai Lee Yap and Hao Liu and Amittha Wickrema and Andrew S. Artz and Koen M. van Besien and Seiya Imoto and Satoru Miyano and Michael R. Bishop and Wendy Stock and Yusuke Nakamura},
  booktitle={Bone Marrow Transplantation},
  year={2015}
}
Allogeneic hematopoietic stem cell transplantation (HSCT) is one of curative treatment options for patients with hematologic malignancies. Although GVHD mediated by the donor’s T lymphocytes remains the most challenging toxicity of allo-HSCT, graft-versus-leukemia (GVL) effect targeting leukemic cells, has an important role in affecting the overall outcome of patients with AML. Here we comprehensively characterized the TCR repertoire in patients who underwent matched donor or haplo-cord HSCT… CONTINUE READING
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Quantitative assessment of T cell repertoire recovery after hematopoietic stem cell transplantation

  • JW van Heijst, I Ceberio, LB Lipuma, DW Samilo, GD Wasilewski, AM Gonzales
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