Quantitative cerebral anatomy of the aging human brain

@article{Coffey1992QuantitativeCA,
  title={Quantitative cerebral anatomy of the aging human brain},
  author={Charles E. Coffey and William E. Wilkinson and LA. Parashos and S A Soady and Roger J. Sullivan and Linda J. Patterson and Gary S. Figiel and Mark Webb and Charles E. Spritzer and William T. Djang},
  journal={Neurology},
  year={1992},
  volume={42},
  pages={527 - 527}
}
Seventy-six healthy adults underwent magnetic resonance imaging (1.5 T) to investigate the effects of age on regional cerebral volumes and on the frequency and severity of cortical atrophy, lateral ventricular enlargement, and subcortical hyperintensity. Increasing age was associated with (1) decreasing volumes of the cerebral hemispheres (0.23% per year), the frontal lobes (0.55% per year), the temporal lobes (0.28% per year), and the amygdalahippocampal complex (0.30% per year); (2… 

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References

SHOWING 1-10 OF 58 REFERENCES
Gender differences in age effect on brain atrophy measured by magnetic resonance imaging.
  • R. Gur, P. Mozley, D. Berretta
  • Medicine, Psychology
    Proceedings of the National Academy of Sciences of the United States of America
  • 1991
TLDR
It is suggested that women are less vulnerable to age-related changes in mental abilities, whereas men are particularly susceptible to aging effects on left hemispheric functions.
Quantitative neuroanatomy in schizophrenia. A controlled magnetic resonance imaging study.
TLDR
The data corroborate third and lateral ventriculomegaly in schizophrenia using magnetic resonance imaging but fail to further localize the structural abnormality.
Quantitative NMR measurements of hippocampal atrophy in Alzheimer's disease
TLDR
The results show that NMR is capable of providing in vivo quantification of diminished hippocampal size in AD which is not cor‐related with overall brain atrophy and which may differentiate AD from normal aging.
Sex Difference in Brain Atrophy During Aging: A Quantitative Study with Computed Tomography
TLDR
A clear difference was observed between men and women in the process of brain atrophy with increasing age and a significant reduction in BVI began in the sixth decade of life and declined significantly again in the seventh and eighth decades.
Imaging of the aging brain. Part I. Normal findings.
TLDR
Since approximately half of the elderly population exhibits only negligible brain alterations, MR imaging may facilitate the distinction between usual (no neurologic dysfunction) and successful (no brain or vascular changes) aging.
A quantitative study of cerebral atrophy in old age and senile dementia
Brain and intracranial cavity volumes: in vivo determination by MRI
TLDR
A non‐invasive technique using MRI which permits the in vivo determination of brain volume, intracranial cavity volume, ventricular, cortical sulcal and total intrac Cranial CSF volumes will make it possible, for the first time, to investigate prospectively the correlation between mental function and brain volume in illness and ageing.
Sensitivity of Cerebral Glucose Metabolism to Age, Gender, Brain Volume, Brain Atrophy, and Cerebrovascular Risk Factors
  • F. Yoshii, W. Barker, R. Duara
  • Medicine
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
  • 1988
TLDR
In this study almost 80% of the variance in CMRglu could not be explained by any of the factors that had been considered, which implies a lack of sensitivity of absolute values of global C MRglu to the mild effects of brain dysfunction.
Temporal lobe pathology in schizophrenia: a quantitative magnetic resonance imaging study.
Although numerous studies have confirmed the presence of larger cerebral ventricles in schizophrenia, the locus of tissue loss remains elusive. By analyzing magnetic resonance scans with computerized
Changes on computed cranial tomography with aging: intracranial fluid volume.
TLDR
The cranial cavity was larger in men than in women, and, in both genders, the left hemicranium and the left ventricle were larger on the average than their right counterparts.
...
...