Quantitative calcium measurements in subcellular compartments of Plasmodium falciparum-infected erythrocytes.

@article{Rohrbach2005QuantitativeCM,
  title={Quantitative calcium measurements in subcellular compartments of Plasmodium falciparum-infected erythrocytes.},
  author={Petra Rohrbach and Oliver Friedrich and Joachim Hentschel and Helmut Plattner and Rainer H. A. Fink and Michael Lanzer},
  journal={The Journal of biological chemistry},
  year={2005},
  volume={280 30},
  pages={27960-9}
}
The acidic food vacuole exerts several important functions during intraerythrocytic development of the human malarial parasite Plasmodium falciparum. Hemoglobin taken up from the host erythrocyte is degraded in the food vacuole, and the heme liberated during this process is crystallized to inert hemozoin. Several anti-malarial drugs target food vacuolar pathways, such as hemoglobin degradation and heme crystallization. Resistance and sensitization to some antimalarials is associated with… CONTINUE READING