Quantitative bone histology in the hypercalcemia of malignant disease.

  title={Quantitative bone histology in the hypercalcemia of malignant disease.},
  author={G D McDonnell and Colin Robert Dunstan and Richard A. Evans and John N. Carter and E E Hills and Siu Yin Wong and D R Mcneil},
  journal={The Journal of clinical endocrinology and metabolism},
  volume={55 6},
Quantitative bone histology was studied in 23 patients with malignant hypercalcemia (MH) due to carcinoma (16) or immunoproliferative disease (7). Plasma calcium was 3.37 +/- 0.47 (mean +/- SD) mmol/liter. Bone resorbing surface (RS) was measured using a sensitive histochemical stain to identify osteoclasts. In the MH patients with carcinoma, the RS was 3.1 +/- 2.6% compared to 1.0 +/- 0.3% in controls (P less than 0.02). In the myeloma patients it was 2.3 +/- 1.7%, and in normocalcemic… CONTINUE READING