Quantitative autoradiography reveals different angiotensin II receptor subtypes in selected rat brain nuclei.

@article{Tsutsumi1991QuantitativeAR,
  title={Quantitative autoradiography reveals different angiotensin II receptor subtypes in selected rat brain nuclei.},
  author={Keisuke Tsutsumi and J M Saavedra},
  journal={Journal of neurochemistry},
  year={1991},
  volume={56 1},
  pages={348-51}
}
Heterogeneity of rat brain angiotensin II receptors was revealed by quantitative autoradiography after incubation with 125I-Sar1-angiotensin II and displacement with the angiotensin II antagonists CGP 42112 A and DuP-753 and by receptor sensitivity to dithiothreitol. Receptors in areas involved in cardiovascular and fluid control--the subfornical organ, nucleus of the solitary tract, paraventricular nucleus, and area postrema--are displaced by DuP-753 with an IC50 of 1 x 10(-7) M, are sensitive… CONTINUE READING
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