Quantitative autoradiography of serotonin uptake sites in rat brain using [3H]cyanoimipramine
@article{Kovachich1988QuantitativeAO, title={Quantitative autoradiography of serotonin uptake sites in rat brain using [3H]cyanoimipramine}, author={Gyula B. Kovachich and Carl E. Aronson and David J. Brunswick and Alan Frazer}, journal={Brain Research}, year={1988}, volume={454}, pages={78-88} }
101 Citations
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A marked decrease in ex vivo [3H] sertraline binding in the brain of rats 7 days after treatment withp-chloroamphetamine was consistent with the loss of serotonin uptake sites induced by this agent.
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Antidepressant agents with properties to inhibit 5-hydroxytryptamine uptake in brain tissue and platelets bind with high affinities to neuronal and platelet membranes and appear to be better ligands than [3H]imipramine.
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The results indicate that [3H]CN-IMI can be given to rats to provide a measure of serotonin uptake sites in the central nervous system in vivo and show that the binding in vivo was saturable.
Selective labeling of serotonin uptake sites in rat brain by [3H]citalopram contrasted to labeling of multiple sites by [3H]imipramine.
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Inhibition of [3H]citalopram binding by both serotonin and imipramine is consistent with a competitive interaction in both equilibrium and kinetic analyses, and the regional distribution of serotonin sensitive and serotonin-insensitive high affinity binding sites closely resembles that of citalopam binding.
Does high affinity [3H] imipramine binding label serotonin reuptake sites in brain and platelet?
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Quantitative Autoradiography of [3H]Indalpine Binding Sites in the Rat Brain: II. Regional Distribution
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The anatomical distribution of binding sites demonstrated is consistent with the specific labelling of 5‐HT neurons by [3H]indalpine and confirms previous studies carried out with another 5-HT uptake inhibitor, [3 H]imipramine.
Distribution of imipramine binding sites in the rat brain studied by quantitative autoradiography
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Single-site model of the neuronal 5-hydroxytryptamine uptake and imipramine-binding site.
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Both displacement and saturation studies in which two displacing agents were combined indicated that most of the binding competed by 5-HT and norzimeldine is identical and is subsumed within 6-MeO-TH beta C (30 microM)-displaceable binding.
Quantitative Autoradiography of [3H]Indalpine Binding Sites in the Rat Brain: I. Pharmacological Characterization
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Electrolytic lesions of the dorsal raphe or medial forebrain bundle, which cause a degeneration of 5‐HT cell bodies and fibers, respectively, resulted in a 30–40% reduction in the binding of [3H]indalpine.
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A nonpeptidic constituent of rat brain capable of displacing [3H]imipramine from its high-affinity binding site and of inhibiting the serotonin uptake in a dose-related manner has been extracted and its partial purification is described.
Quantitative autoradiographic localization of [3H]imipramine binding sites in the brain of the rat: relationship to ascending 5-hydroxytryptamine neuron systems.
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The present results underline the possibility that the 5-HT and dopamine hypotheses for the mechanism of action of antidepressant drugs are not mutually exclusive, because both 5- HT and dopamine neurons can be regulated by large numbers of [3H]imipramine binding sites.