Quantitative autoradiography of angiotensin II receptors in the SHR brain

  title={Quantitative autoradiography of angiotensin II receptors in the SHR brain},
  author={Donald R. Gehlert and Robert C Speth and James K. Wamsley},
Several lines of evidence indicate brain angiotensin II is associated with the elevation of blood pressure seen in the spontaneously hypertensive rat (SHR). These include an increased pressor response to intracerebroventricularly administered angiotensin II and a reduction of blood pressure in response to centrally administered angiotensin II receptor antagonists. Using quantitative receptor autoradiography, we have detected greater angiotensin II receptor binding in a number of discrete brain… CONTINUE READING
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