Quantitative autoradiographic distribution and pharmacological characterization of (3H)buspirone binding to sections from rat, bovine and marmoset brain

@article{Bruening1989QuantitativeAD,
  title={Quantitative autoradiographic distribution and pharmacological characterization of (3H)buspirone binding to sections from rat, bovine and marmoset brain},
  author={George E Bruening and P. Kaulen and Udo Schneider and Hans Georg Baumgarten},
  journal={Journal of Neural Transmission / General Section JNT},
  year={1989},
  volume={78},
  pages={131-144}
}
(3H)Buspirone binds with high affinity (KD =11 nM) to sections from rat striatum. Spiroperidol, chlorpromazine, (+)-butaclamol and apomorphine are the most potent inhibitors of (3H)buspirone binding. Ketanserin, SCH 23390, serotonin and phentolamine are clearly less active. The regional distribution of (3H)buspirone binding in rat and marmoset brain is characterized by high silver grain densities in the olfactory tubercle, nucleus accumbens and striatum. In the hypophysis, the pars intermedia… CONTINUE READING