Quantitative assessment of serum and urinary polyclonal free light chains in patients with chronic kidney disease.

@article{Hutchison2008QuantitativeAO,
  title={Quantitative assessment of serum and urinary polyclonal free light chains in patients with chronic kidney disease.},
  author={C. A. Hutchison and Stephen Harding and Pete Hewins and Graham Peter Mead and John N. Townsend and Arthur R Bradwell and Paul Cockwell},
  journal={Clinical journal of the American Society of Nephrology : CJASN},
  year={2008},
  volume={3 6},
  pages={1684-90}
}
BACKGROUND AND OBJECTIVES Monoclonal free light chains (FLC) frequently cause kidney disease in patients with plasma cell dyscrasias. Polyclonal FLC, however, have not been assessed in patients with chronic kidney disease (CKD) yet could potentially play an important pathologic role. This study describes for the first time polyclonal FLC in patients with CKD. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS A sensitive, quantitative immunoassay was used to analyze serum and urinary polyclonal… CONTINUE READING
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