Quantitative assessment of neuroprotection against NMDA-induced brain injury

@article{McDonald1989QuantitativeAO,
  title={Quantitative assessment of neuroprotection against NMDA-induced brain injury},
  author={J. W. McDonald and Nancy F. Roeser and Faye Sarah Silverstein and Michael V Johnston},
  journal={Experimental Neurology},
  year={1989},
  volume={106},
  pages={289-296}
}
In immature rodent brain, unilateral intrastriatal injections of selected excitatory amino acid (EAA) receptor agonists, such as N-methyl-D-aspartate (NMDA), produce prominent ipsilateral forebrain lesions. In Postnatal Day (PND) 7 rats that receive a right intrastriatal injection of NMDA (25 nmol) and are sacrificed 5 days later, there is a considerable and consistent reduction in the weight of the injected cerebral hemisphere relative to that of the contralateral side (-28.5 +/- 1.9%, n = 6… CONTINUE READING
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