Quantitative assessment of molecular remission after high-dose therapy with autologous stem cell transplantation predicts long-term remission in mantle cell lymphoma.

@article{Pott2006QuantitativeAO,
  title={Quantitative assessment of molecular remission after high-dose therapy with autologous stem cell transplantation predicts long-term remission in mantle cell lymphoma.},
  author={Christiane Pott and Carsten Schrader and Stefan Gesk and Lana Harder and Markus Tiemann and Thorsten Raff and Monika Br{\"u}ggemann and Matthias Ritgen and Benedikt Gahn and Michael Unterhalt and Martin P Dreyling and Wolfgang Hiddemann and Reiner Siebert and Peter Dreger and Michael Kneba},
  journal={Blood},
  year={2006},
  volume={107 6},
  pages={2271-8}
}
To evaluate the prognostic impact of minimal residual disease (MRD), quantitative real-time polymerase chain reaction (RQ-PCR) of clonal IGH rearrangements was performed in 29 patients with mantle cell lymphoma (MCL) treated with high-dose radiochemotherapy and autologous stem cell transplantation (ASCT). Fourteen of 27 patients evaluable for MRD after ASCT achieved complete clinical and molecular remission, whereas 13 patients had detectable MRD within the first year after ASCT. Molecular… CONTINUE READING
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